Icon Representing Symptoms Associated with Hypereosinophilic Syndrome (HES) Icon Representing Symptoms Associated with Hypereosinophilic Syndrome (HES)

What are the signs and symptoms of hypereosinophilic syndrome (HES)?

HES can affect different organs, including skin, lungs, stomach, GI tract, heart, nerves, joints, blood vessels, and other organs. Multiple organs can be affected at the same time, and symptoms will vary depending on which organs are affected.

Watch out for symptoms

Each person’s symptoms are unique, however common symptoms can include fatigue, fever, cough, rash, stomach pain, or shortness of breath. These symptoms can change over time and worsen without treatment.

Work with your doctor

Understanding and diagnosing HES can be difficult because it's a rare condition that many doctors do not see often, and it requires ruling out other possible causes first. If you suspect you have HES, it's important to work closely with your healthcare provider to reach the right diagnosis.

Patients with HES may be diagnosed and managed by a team of specialists, such as an allergist/immunologist, pulmonologist, hematologist, cardiologist, and/or other relevant specialists. The doctor who diagnosed you can help you determine which specialists you need.

Icon Representing Discussing Hypereosinophilic Syndrome (HES) Icon Representing Discussing Hypereosinophilic Syndrome (HES)

FASENRA is approved to treat people 12 years and older with HES.

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frequently asked questions

HES is a condition in which high levels of eosinophils—a type of white blood cell—can lead to inflammation, tissue damage, and eventually, organ damage.

Eosinophil levels for patients with HES are often around 10 times normal level.

HES can affect different organs, including skin, lungs, stomach, GI tract, heart, nerves, joints, blood vessels, and other organs. Multiple organs can be affected at the same time, and symptoms will vary depending on which organs are affected.

Each person’s symptoms are unique, however common symptoms can include tiredness, fever, cough, rash, stomach pain, or shortness of breath, and they can change over time and worsen without treatment.

 

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IMPORTANT SAFETY INFORMATION

Do not use FASENRA if you are allergic to benralizumab or any of the ingredients in FASENRA. Do not use to treat sudden breathing problems.

 

FASENRA may cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your FASENRA injection. Allergic reactions can sometimes happen hours or days after you get your injection. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth and tongue
    • breathing problems
    • fainting, dizziness, feeling lightheaded (low blood pressure)
    • rash
    • hives

Before using FASENRA, tell your healthcare provider about all of your medical conditions, including if you:

  • are taking oral or inhaled corticosteroid medicines. Do not stop taking your corticosteroid medicines unless instructed by your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back
  • have a parasitic (helminth) infection
  • are pregnant or plan to become pregnant. It is not known if FASENRA will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with FASENRA
  • are breastfeeding or plan to breastfeed. It is not known if FASENRA passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use FASENRA
  • are taking prescription and over-the-counter medicines, vitamins, or herbal supplements.

Do not stop taking your other medicines unless instructed to do so by your healthcare provider. Tell your healthcare provider if your condition does not get better or if it gets worse after you start treatment with FASENRA.

The most common side effects of FASENRA:

  • adults and children 6 years and older with asthma include headache and sore throat
  • adults with EGPA include headache
  • adults and children 12 years and older with HES include headache, allergic reactions, and flu-like symptoms

These are not all the possible side effects of FASENRA.

APPROVED USE

FASENRA is a prescription medicine used:

  • with other asthma medicines for the maintenance treatment of asthma in adults and children 6 years and older whose asthma is not controlled with their current asthma medicines. FASENRA is not used to treat sudden breathing problems.
  • to treat adults with eosinophilic granulomatosis with polyangiitis (EGPA).
  • to treat adults and children 12 years and older with hypereosinophilic syndrome (HES).

Please see full Prescribing Information, including Patient Information and Instructions for Use.

You may report side effects related to AstraZeneca products.