What does FASENRA do?

FASENRA is a biologic medication approved to treat hypereosinophilic syndrome (HES). It is designed to target and remove eosinophils, which play a role in HES. The mechanism of action of FASENRA in HES is not fully understood.

What are eosinophils, and how are they related to HES?

Eosinophils are white blood cells, a normal part of our immune system. When you have HES, a rare disorder, your body has too many eosinophils.

Having a high number of eosinophils in the blood can eventually lead to tissue and multiple organ damage as these eosinophils can enter tissues and cause inflammation. HES can affect any organ in the body, including skin, lungs, stomach, GI tract, heart, nerves, joints, blood vessels, and other organs.

FASENRA is the only FDA-approved HES treatment that is

FASENRA is the only FDA-approved HES treatment that is

ONE INJECTION
EVERY 4 WEEKS*

Icon Of a Calendar Representing a FASENRA Injection Schedule For Hypereosinophilic Syndrome Icon Of a Calendar Representing a FASENRA Injection Schedule For Hypereosinophilic Syndrome

*Dosing comparisons do not imply improved efficacy or safety.

Icon Of a Calendar Representing a FASENRA Injection Schedule For Hypereosinophilic Syndrome Icon Of a Calendar Representing a FASENRA Injection Schedule For Hypereosinophilic Syndrome

Administration options include:

Icon Representing a Healthcare Professional Can Administer FASENRA At Their Office Icon Representing a Healthcare Professional Can Administer FASENRA At Their Office

At Your Doctor’s Office

Your healthcare provider can administer FASENRA at their office.

Icon Representing Home Administration Of Treatment For Hypereosinophilic Syndrome (HES) Icon Representing Home Administration Of Treatment For Hypereosinophilic Syndrome (HES)

At Home

If you and your doctor decide that you will self-administer with the FASENRA Pen, you will receive proper training from a healthcare provider.

Read more

IMPORTANT SAFETY INFORMATION

Do not use FASENRA if you are allergic to benralizumab or any of the ingredients in FASENRA. Do not use to treat sudden breathing problems.

 

FASENRA may cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your FASENRA injection. Allergic reactions can sometimes happen hours or days after you get your injection. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth and tongue
    • breathing problems
    • fainting, dizziness, feeling lightheaded (low blood pressure)
    • rash
    • hives

Before using FASENRA, tell your healthcare provider about all of your medical conditions, including if you:

  • are taking oral or inhaled corticosteroid medicines. Do not stop taking your corticosteroid medicines unless instructed by your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back
  • have a parasitic (helminth) infection
  • are pregnant or plan to become pregnant. It is not known if FASENRA will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with FASENRA
  • are breastfeeding or plan to breastfeed. It is not known if FASENRA passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use FASENRA
  • are taking prescription and over-the-counter medicines, vitamins, or herbal supplements.

Do not stop taking your other medicines unless instructed to do so by your healthcare provider. Tell your healthcare provider if your condition does not get better or if it gets worse after you start treatment with FASENRA.

The most common side effects of FASENRA:

  • adults and children 6 years and older with asthma include headache and sore throat
  • adults with EGPA include headache
  • adults and children 12 years and older with HES include headache, allergic reactions, and flu-like symptoms

These are not all the possible side effects of FASENRA.

APPROVED USE

FASENRA is a prescription medicine used:

  • with other asthma medicines for the maintenance treatment of asthma in adults and children 6 years and older whose asthma is not controlled with their current asthma medicines. FASENRA is not used to treat sudden breathing problems.
  • to treat adults with eosinophilic granulomatosis with polyangiitis (EGPA).
  • to treat adults and children 12 years and older with hypereosinophilic syndrome (HES).

Please see full Prescribing Information, including Patient Information and Instructions for Use.

You may report side effects related to AstraZeneca products.