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Starting with FASENRA

Before using your FASENRA PEN, your healthcare provider should show you or your caregiver how to use it the right way.

In people aged 6 to 11 years, FASENRA should only be given by a caregiver or healthcare provider.

Read the Instructions for Use before you start using your FASENRA PEN and each time you get a refill.

If you or your caregiver have any questions, talk to your healthcare provider.

Your FASENRA Pen

Do not remove the cap until you have reached Step 6 of these instructions and are ready to inject FASENRA.

Labeled Illustration of the FASENRA Pen Showing Before & After Use Labeled Illustration of the FASENRA Pen Showing Before & After Use

How it works

Illustration Showing How to Use FASENRA Pen Illustration Showing How to Use FASENRA Pen

The injection starts automatically when the green needle guard is pushed against the skin.

You must keep the pen pressed down firmly for 15 seconds to deliver the full dose.

The injection is finished when the green plunger fills the viewing window.

Each FASENRA PEN contains 1 dose of FASENRA that is for one-time use only.

Storage

Store FASENRA in a refrigerator between 36°F to 46°F (2°C to 8°C) in its original carton until you are ready to use it.

Once removed from the refrigerator and brought to room temperature, FASENRA must be used within 14 days or thrown away (disposed of).

Keep FASENRA and all medicines out of the sight and reach of children. 

Safety precautions

Do not use your FASENRA PEN if:

  • it has been frozen
  • it has been dropped or damaged
  • the security seal on the carton has been broken
  • the expiration date (EXP) has passed

Do not:

  • shake your FASENRA PEN
  • share or reuse your FASENRA PEN
  • expose your FASENRA PEN to heat

If any of these happen, throw away the FASENRA PEN in a puncture-resistant sharps disposal container and use a new FASENRA PEN.

1Gather supplies

Supplies For Preparing The FASENRA Pen Supplies For Preparing The FASENRA Pen

See Step 10 for instructions on how to throw away (dispose of) the used FASENRA PEN safely.

2Prepare to use your FASENRA PEN

Check the expiration date (EXP). Do not use if the expiration date has passed.

30‑Minute Timer Icon for Injection Preparation 30‑Minute Timer Icon for Injection Preparation

Let FASENRA warm up at room temperature between 68°F to 77°F (20°C to 25°C) for about 30 minutes before giving the injection.

Use FASENRA within 14 days of removing it from the refrigerator. After 14 days, throw away the FASENRA PEN.

Do not:

  • warm the FASENRA PEN in any other way. For example, do not warm it in a microwave or hot water, or put it near other heat sources
  • remove the cap until you have reached Step 6

3Check the liquid

Image Showing How to Check the Liquid in the FASENRA Pen Image Showing How to Check the Liquid in the FASENRA Pen

Look at the liquid in the FASENRA PEN through the viewing window. The liquid should be clear and colorless to slightly yellow. It may contain small white particles.

Do not inject FASENRA if the liquid is cloudy, discolored, or contains large particles.

You may see small air bubbles in the liquid. This is normal. You do not need to do anything about it.

4Choose the injection site

If you are giving yourself the injection, the recommended injection site is the front of your thigh or the lower part of your stomach (abdomen).

A caregiver may inject you in the upper arm, thigh, or abdomen. Do not try to inject yourself in the arm.

Injection Site Areas Shown on Body Outline Injection Site Areas Shown on Body Outline

For each injection, choose a different site that is at least 1-inch (3-cm) away from where you last injected.

Do not inject:

  • into the 2-inch (5-cm) area around your belly button
  • where the skin is tender, bruised, scaly or hard
  • into scars or damaged skin
  • through clothing

5Clean the injection site

Image showing Cleaning the Injection Site Image showing Cleaning the Injection Site

Wash your hands well with soap and water.

Clean the injection site with an alcohol wipe in a circular motion. Let it air dry.

Do not:

  • touch the cleaned area before injecting
  • fan or blow on the cleaned area

6Pull off the cap

Pull Off the Cap of FASENRA Pen Pull Off the Cap of FASENRA Pen

Hold the FASENRA PEN with 1 hand. Carefully pull the cap straight off with your other hand. Put the cap aside to throw away later.

The green needle guard is now exposed. It is there to prevent you from touching the needle.

Do not:

  • try to touch the needle or push on the needle guard with your finger
  • try to put the cap back on the FASENRA PEN

Complete the following steps right away after removing the cap.

7Inject FASENRA for 15 seconds

What to know first

Inject FASENRA by following the steps in figures a, b, c, and d.

Hold the FASENRA PEN in place for the entire injection. Do not change the position of the FASENRA PEN after the injection has started.

You can either gently pinch at the injection site or give the injection without pinching the skin. Follow your healthcare providers instructions.

Position the FASENRA PEN at the injection site. 

Step For FASENRA Pen Positioned at Injection Site At 90 Degrees Step For FASENRA Pen Positioned at Injection Site At 90 Degrees

Place the needle guard of the FASENRA PEN flat against your skin (90-degree angle). Make sure you can see the viewing window.

Press down firmly.

Step 2 to Press FASENRA Pen Down Firmly to Start Injection Step 2 to Press FASENRA Pen Down Firmly to Start Injection

You will hear a click. A ‘click’ tells you the injection has started. The green plunger will move down in the viewing window during the injection. 

Hold down firmly for 15 seconds. 

Step 3 to Hold Injector Down For 15 Seconds During Injection Step 3 to Hold Injector Down For 15 Seconds During Injection

You will hear a second ‘click.’ The second click tells you the injection has finished. The green plunger will fill the viewing window.

Lift the FASENRA PEN straight up. 

Step 4 To Lift the Autoinjector Straight Up After Injection Step 4 To Lift the Autoinjector Straight Up After Injection

The needle guard will slide down and lock into place over the needle. 

Video: Summary of injection steps 

8Check the viewing window

Step To Check the FASENRA Pen For Viewing Window Before and After Step To Check the FASENRA Pen For Viewing Window Before and After

Check the viewing window to make sure all the liquid has been injected. 

If the green plunger does not fill the viewing window, you may not have received the full dose. If this happens or if you have any other concerns, call your healthcare provider.

9Check the injection site

Check The Injection Site with Gauze After Injection Check The Injection Site with Gauze After Injection

There may be a small amount of blood or liquid where you injected. This is normal. 

Gently hold pressure over your skin with a cotton ball or gauze until the bleeding stops. Do not rub the injection site. 

If needed, cover the injection site with a small bandage.

10Dispose

Step To Dispose the Used Autoinjector in a Sharps Disposal Container Step To Dispose the Used Autoinjector in a Sharps Disposal Container

Each FASENRA PEN contains a single dose of FASENRA and cannot be reused. Put your used FASENRA PEN in an FDA-cleared sharps disposal container right away after use.

Do not throw away the FASENRA PEN in your household trash. 

Throw away the cap and other used supplies in your household trash. 

If you do not have a FDA-cleared sharps disposal container, you may use a household container that is:

  • made of a heavy-duty plastic,
  • closed with a tight-fitting puncture-resistant lid, without sharps being able to come out,
  • upright and stable during use,
  • leak resistant, and
  • properly labeled to warn of hazardous waste inside the container.

When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the area that you live in, go to the FDA’s website.

Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this.

Do not recycle your used sharps disposal container.

For more information about self-injection, see

Frequently asked questions

For an overview on how to start, see

Instructions for Use - How to video

For a range of support services, see

FASENRA 360

To download a custom Dose Calendar, see

FASENRA Dosing CalendarFASENRA Dosing CalendarFASENRA Dosing Calendar

Read more

IMPORTANT SAFETY INFORMATION

Do not use FASENRA if you are allergic to benralizumab or any of the ingredients in FASENRA. Do not use to treat sudden breathing problems.

 

FASENRA may cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your FASENRA injection. Allergic reactions can sometimes happen hours or days after you get your injection. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth and tongue
    • breathing problems
    • fainting, dizziness, feeling lightheaded (low blood pressure)
    • rash
    • hives

Before using FASENRA, tell your healthcare provider about all of your medical conditions, including if you:

  • are taking oral or inhaled corticosteroid medicines. Do not stop taking your corticosteroid medicines unless instructed by your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back
  • have a parasitic (helminth) infection
  • are pregnant or plan to become pregnant. It is not known if FASENRA will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with FASENRA
  • are breastfeeding or plan to breastfeed. It is not known if FASENRA passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use FASENRA
  • are taking prescription and over-the-counter medicines, vitamins, or herbal supplements.

Do not stop taking your other medicines unless instructed to do so by your healthcare provider. Tell your healthcare provider if your condition does not get better or if it gets worse after you start treatment with FASENRA.

The most common side effects of FASENRA:

  • adults and children 6 years and older with asthma include headache and sore throat
  • adults with EGPA include headache
  • adults and children 12 years and older with HES include headache, allergic reactions, and flu-like symptoms

These are not all the possible side effects of FASENRA.

APPROVED USE

FASENRA is a prescription medicine used:

  • with other asthma medicines for the maintenance treatment of asthma in adults and children 6 years and older whose asthma is not controlled with their current asthma medicines. FASENRA is not used to treat sudden breathing problems.
  • to treat adults with eosinophilic granulomatosis with polyangiitis (EGPA).
  • to treat adults and children 12 years and older with hypereosinophilic syndrome (HES).

Please see full Prescribing Information, including Patient Information and Instructions for Use.

You may report side effects related to AstraZeneca products.