EGPA FAQs

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare autoimmune disorder that often results in inflammation of blood vessels and a high number of white blood cells known as eosinophils (e-o-SIN-o-phils). Inflammation and damage to your blood vessels related to EGPA can restrict the amount of blood that reaches tissues and organs throughout your body. This can cause different effects throughout the body and irreversible damage if left untreated.

Everyone has eosinophils. They are white blood cells and a normal part of your immune system. If you have EGPA, that means your eosinophil count is high. A high number of eosinophils in your blood can lead to inflammation throughout your body to various tissues and organs.

Tell your doctor if you:

• are taking oral or inhaled corticosteroid medicines
• have a parasitic (helminth) infection
• are pregnant or plan to become pregnant
• are breastfeeding or plan to breastfeed
• are taking prescription and over-the-counter medicines, vitamins, or herbal supplements

Do not stop taking your other EGPA medicines unless instructed to do so by your doctor.

FASENRA is a prescription medicine approved to help treat people 18 years and older with EGPA. It's a biologic treatment given by injection once every 4 weeks.

The mechanism of action of FASENRA in EGPA is not fully understood.

The FASENRA prefilled syringe is an injection administered under the skin (subcutaneously) by a healthcare provider.

The FASENRA Pen is an injection administered under the skin (subcutaneously) by the patient, caregiver, or healthcare provider. Do not try to inject the FASENRA Pen until you have been trained by your healthcare provider.

FASENRA is designed to target and remove eosinophils, which play a role in EGPA. The mechanism of action of FASENRA in EGPA is not fully understood.

Do not use FASENRA if you are allergic to benralizumab or any of the ingredients in FASENRA. Click here for full Important Safety Information.

FASENRA is 1 injection every 4 weeks.

Each FASENRA dose is very important, so if you miss a dose of FASENRA, call your healthcare provider. Stay on track with your treatment and help reduce your chances of forgetting a dose. Click here to sign up for dose reminders or a dose calendar.

Many factors determine how much you will pay for FASENRA. You could pay as little as $0. The FASENRA Savings Program is for commercially insured patients to cover patient out-of-pocket costs for FASENRA and its administration, up to $13,000 per calendar year.

If you need help paying for FASENRA, AstraZeneca may be able to help. You can get more information on FASENRA affordability programs by calling 1-833-360-HELP (4357).

FASENRA 360 provides a range of support services if you are on FASENRA, including reimbursement support, affordability programs if you are eligible, nursing support for FASENRA questions including injection training and support for FASENRA Pen,* and ongoing education. Call 1-833-360-HELP (4357) Monday–Friday, 8 AM to 6 PM ET.

^*Information from our nurses does not replace the advice or training from your physician or other healthcare providers. Nurses cannot provide diagnosis or treatment advice to callers.

If you are having any problems with your FASENRA Pen, call FASENRA 360 at 1-833-360-HELP (4357) for assistance. Also, let your doctor know.

If you think that your FASENRA Pen is damaged, call FASENRA 360 at 1-833-360-HELP (4357) for assistance. Also, let your doctor know.

Store FASENRA in a refrigerator between 36°F to 46°F (2°C to 8°C) in its original carton until you are ready to use it. FASENRA may be kept at room temperature between 68°F to 77°F (20°C to 25°C) for a maximum of 14 days. Once removed from the refrigerator and brought to room temperature, FASENRA must be used within 14 days or thrown away (disposed of).

Yes, a trained caregiver or healthcare provider can administer your FASENRA injection for you.

Your doctor is the best source of information for your health and how to self-administer. If you would like additional information on how to inject your FASENRA Pen, you can call FASENRA 360 at 1-833-360-HELP (4357).

Click here to read the full Instructions for Use about how to self-administer your FASENRA Pen. Or, you can also watch a step-by-step Instructional video here. Both will show you how to self-administer your FASENRA Pen.

Each FASENRA Pen contains 1 dose of FASENRA that is for one-time use only. Once you have completed the injection process, immediately dispose of the Pen in an FDA-cleared Sharps Disposal Container. Do not throw away the Pen in your household trash. Throw away the cap and other used supplies in your trash.

AstraZeneca is committed to keeping FASENRA Pens out of landfills. We can send you a Sharps Disposal Container to safely dispose of your FASENRA Pens. Simply drop the Pen inside the Sharps Disposal Container right after use. Log the date on the container to track your treatments. After your 10th dose, repackage the container in the box it came in and ship with the USPS pre-paid label. When your full Sharps Disposal Container is received, we will mail you a new one. To obtain a Sharps Disposal Container, call FASENRA 360 at 1-833-360-HELP (4357). Your Specialty Pharmacy may also have options available.

Your Specialty Pharmacy can provide alcohol wipes and cotton balls or gauze. FASENRA 360 can also provide a Sharps Disposal Container so you can properly dispose of your used FASENRA Pen.

Always talk with your healthcare provider before traveling. If you have questions, check the latest TSA guidelines at www.tsa.gov before flying to make sure you’re aware of the most up-to-date information. FASENRA 360 can provide an Insulated Travel Bag to help you travel with your medication. Please call FASENRA 360 at 1-833-360-HELP (4357) for more information.