FASENRA HELPS PREVENT SEVERE ASTHMA ATTACKS

FASENRA is an add-on maintenance treatment for patients aged 12 and older with severe eosinophilic asthma. FASENRA targets cells in your body called eosinophils, which can be a key cause of severe asthma. FASENRA is not an inhaler or a steroid. FASENRA is an injection given by a healthcare provider—one dose every 8 weeks after the first 2 months.*

*First 3 doses given on day 1, week 4, and week 8.

FASENRA—PROVEN PREVENTION

FASENRA has been studied in the largest clinical trial program for targeted therapies in severe eosinophilic asthma. FASENRA worked better than standard asthma treatments alone.

Your results may vary.

WHEN ADDED TO CURRENT ASTHMA TREATMENTS, FASENRA WAS CLINICALLY PROVEN TO:

Reduce the occurrence of severe asthma attacks by up to
 
Improve lung function for better breathing
 

IN PATIENTS TAKING DAILY ORAL STEROIDS, FASENRA:

Reduced the use of oral steroids by
 
Helped some patients completely stop using oral steroids
 

Don’t stop your asthma treatments, including corticosteroids, unless your doctor tells you to.

*In a 48-week clinical trial of FASENRA vs placebo + existing medicines. In a 56-week clinical trial, FASENRA reduced the occurrence of severe asthma attacks by 28% compared with placebo + existing medicines.

Median reduction, compared with 25% with placebo and existing medicines in a 28-week clinical trial of FASENRA vs placebo + steroid + existing medicines.

Only in patients taking a daily dose of 12.5 mg or less.

FASENRA DOSING

Maintenance dosing schedule every 8 weeks

1DOSE

Other Treatments 2-4 DOSES

FASENRA is a targeted asthma medicine given once every 8 weeks after the first 2 months.*

In 2 clinical trials, injection site reactions occurred at a rate of 2.2% in patients treated with FASENRA vs 1.9% in patients treated with placebo (eg, pain, redness, itching, swelling near where the injection was given).

*First 3 doses given on day 1, week 4, and week 8.

HOW FASENRA WORKS

Eosinophils are a normal part of the immune system, but people living with eosinophilic asthma have too many. Watch how FASENRA works to target and remove eosinophils.

The mechanism of action of FASENRA in asthma is not fully understood.

1.TARGETS EOSINOPHILS

Thumbnail for How FASENRA Works video.

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2. ACTIVATES YOUR IMMUNE SYSTEM

FASENRA works with your body to attract specific cells in your immune system. These cells break down eosinophils and remove them naturally.

A study has shown that FASENRA targets and nearly eliminates eosinophils from the blood.

THE RISKS AND SIDE EFFECTS OF FASENRA

FASENRA may cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your FASENRA injection. Allergic reactions can sometimes happen hours or days after you get your injection. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth and tongue
    • breathing problems
    • fainting, dizziness, feeling lightheaded (low blood pressure)
    • rash
    • hives

The most common side effects of FASENRA include: headache and sore throat. These are not all the possible side effects of FASENRA.

The safety information above does not replace discussions with your healthcare provider about your medical condition or treatment. Please read Patient Information and Prescribing Information for FASENRA.

Before receiving FASENRA, tell your healthcare provider about all of your medical conditions, including if you:

  • are taking oral or inhaled corticosteroid medicines. Do not stop taking your corticosteroid medicines unless instructed by your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back.
  • have a parasitic (helminth) infection.
  • are pregnant or plan to become pregnant. It is not known if FASENRA will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with FASENRA.
  • are breastfeeding or plan to breastfeed. It is not known if FASENRA passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you receive FASENRA.
  • are taking prescription and over-the-counter medicines, vitamins, or herbal supplements.
  • Do not stop taking your other asthma medicines unless instructed to do so by your healthcare provider.

Important Safety Information

Do not receive FASENRA if you are allergic to benralizumab or any of the ingredients in FASENRA. Do not use to treat sudden breathing problems.

FASENRA may cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after you get your FASENRA injection. Allergic reactions can sometimes happen hours or days after you get your injection. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth and tongue
    • breathing problems
    • fainting, dizziness, feeling lightheaded (low blood pressure)
    • rash
    • hives

Before receiving FASENRA, tell your healthcare provider about all of your medical conditions, including if you:

  • are taking oral or inhaled corticosteroid medicines. Do not stop taking your corticosteroid medicines unless instructed by your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back.
  • have a parasitic (helminth) infection.
  • are pregnant or plan to become pregnant. It is not known if FASENRA will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with FASENRA.
  • are breastfeeding or plan to breastfeed. It is not known if FASENRA passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you receive FASENRA.
  • are taking prescription and over-the-counter medicines, vitamins, or herbal supplements.

Do not stop taking your other asthma medicines unless instructed to do so by your healthcare provider.

The most common side effects of FASENRA include: headache and sore throat. These are not all the possible side effects of FASENRA.

APPROVED USE

FASENRA is a prescription medicine used with other asthma medicines for the maintenance treatment of asthma in people 12 years and older whose asthma is not controlled with their current asthma medicines. FASENRA helps prevent severe asthma attacks (exacerbations) and may improve your breathing. Medicines such as FASENRA reduce blood eosinophils. Eosinophils are a type of white blood cell that may contribute to your asthma.

FASENRA is not used to treat other problems caused by eosinophils and is not used to treat sudden breathing problems. Tell your health care provider if your asthma does not get better or if it gets worse after you start treatment with FASENRA.

It is not known if FASENRA is safe and effective in children under 12 years of age.

Please see full Prescribing Information including Patient Information for FASENRA.

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